
Intranasal bleeding
Chronic sinusitis
Intranasal bleeding

Around 10% of general population suffers from spontaneous nose bleeding (not related to a surgical intervention), of which 10% needs specific medical management (1).


Intranasal bleeding (epistaxis) are from various origins:


Epistaxis can provoke the following symptoms:
Intranasal bleeding is very common, costly and has a negative impact on patient’s quality of life. This is particularly noticeable in Chronic cases (3), epistaxis also greatly impact caregivers quality of life. The “disease” incidence is increasing due to population ageing and exacerbated by the growth of the number of patients suffering from cardiovascular diseases and being treated with anticoagulants.
(1) Changing Trends in the Management of Epistaxis, Traboulsi H et al. International Journal of Otolaryngology Volume 2015
(2) https://biology.stackexchange.com/questions/19827/can-nosebleeds-cause-death
(3) Patients « Rendu-Osler »
Chronic sinusitis

About 12% of the population suffers from chronic sinusitis (1), i.e. 900 million patients worldwide. It is the 5th most frequent disease amongst people aged below 65 years (2). It is more frequent than cardiovascular diseases.


Chronic sinusitis is an inflammatory disease in which sinus mucosa is swollen and inflamed (Figure 1).
FIGURE 1 –Sinusitis : illustration
Chronic sinusitis is caused by:


Chronic sinusitis can provoke the following symptoms:
Persistence of those symptoms can seriously impair daily patients wellness, which causes:
Disease incidence is also increasing (7, 8, 9). This could be explained by pollution growth (industrial or caused by urgent expansion) and antibiotics resistance (10, 11), which usage in sinusitis represents 21% of total antibiotics prescriptions (12) in adults in the US.